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encabezado cascara sagrada

HERBAL MEDICINE TRADITIONALLY USED AS A LAXATIVE.

Cascara Sagrada (Rhamnus purshiana D.C.) is a small deciduous tree with eliptical leaves originating in North America.Its slightly rough bark is dark gray or reddish brown.Its main active ingredients, anthracene or anthraquinone glycosides, form in the leaves and are stored in the bark.The stems and dried bark from the trunk are the part of the plant that is thus used.This raw material must contain at least 8% anthracenes, 60% of which must be cascarosides.

Aloe spp
Aloe spp is a perennial plant originating in North Africa that belongs to the Lilaceae family. It can grow up to 13 meters tall.It has a short stalk with large, thick, fleshy, grayish green leaves. Some species are mottled and have teeth along the edges.The dried juice is used, which is obtained by cutting the leaves transversely.This dried juice must contain at least 18% hydroxyanthracene derivatives in the form of barbaloin.

Constipation
Although bowel movements occur on average once per day, between three bowel movements per day and three bowel movements per week may be considered normal.A person is considered to be constipated when bowel movements occur less than once every 2-3 days.Constipation often appears along with other types of irritation such as distension, bloating and abdominal discomfort.It can be caused by changes in diet, bad eating habits, psychological factors, lack of exercise, travel, convalescence due to fever and the side effects of numerous drugs; in most cases; however, the cause of chronic constipation is functional. Treatment of chronic constipation must never begin with medication, but rather with a physical exercise program and a change in eating habits, which includes an increase in the amount of liquids ingested andeating fruits such as plums, figs, dates and vegetables that are high in fiber.

Anthranoid laxatives
The anthraquinones from cascara sagrada or aloe are colon-specific stimulant laxatives that act directly on intestinal mucosa, increasing colonic motility, improving intestinal transit time and inhibiting the absorption of water and electrolytes.After an oral dose, the anthraquinone glycosides are poorly absorbed in the small intestine and arrive inactive in the large intestine.As glycosides (an aglycone plus a reducing sugar), the colonic bacteria release aglycone, which irritates the nerve endings of the intestinal wall and thus produce an increase in peristalsis and water secretion to the lumen (intestinal cavity).Since the laxative effect is limited mainly to the large intestine by irritating and stimulating the colon, evacuation usually occurs between 8 and 24 hours after ingestion.

QUALITATIVE AND QUALITATIVE COMPOSITION

Each capsule contains

Cascara sagrada (Rhamus purshiana D.C.), dried bark…………..……………..150mg
Aloe spp., dried juice…………………………………………………………………100mg
Excipients (maltodextrin, magnesium stearate, silicon dioxide)………………….. c.s

Traditional Use
Herbal medicine traditionally used as a laxative for constipation, specifically in the case of cardiovascular disease, hemorrhoids, during post-surgery, and for short periods only when other types of treatments have failed, such as changes in diet or the use of “bulk forming” (fiber) laxatives.

Dosage
2 capsules daily.Take with abundant water.Evacuation occurs later, usually between 8 and 24 hours after administration.

Presentation
Boxes of 30 and 60 capsules, and blister packs with 10 capsules.

Storage
Store in a cool, dark, dry place out of reach of children.

Precautions
Please consult your physician before consuming this product.
Not to be used during pregnancy and nursing. Not to be used by children.
Keep this and all medicines out of reach of children.

Restrictions for Use: Not to be used during pregnancy and nursing or by children under 18Not to be used by those with confirmed or suspected intestinal obstruction.Not to be used by patients with inflammatory bowel disease, such as Crohn’s disease and ulcerative colitisNot to be used by patients with suspected or confirmed appendicitis,undiagnosed abdominal pain ora hypersensitivity to the principal active ingredients.

Undesired Side Effects: Prolonged periods of use or high dosages can cause hydroelectrolytic imbalances (most frequently the loss of potassium), albuminuria, hematuria, pigment deposits in the intestinal mucus (pseudomelanosis coli) and colonic atony.All of these problems usually disappear once medication is stopped; nevertheless, potassium loss may lead to muscular and/or cardiac abnormalities, particularly in patients receiving concomitant digitalis therapy, diuretics and/or corticosteroids.

Precautions: Laxatives of this type should only be ingested for brief periods of time, usually no more than one week.Prolonged periods of use produce symptoms of abuse.Do not exceed the recommended dosage.If you are taking other medications, please consult your physician before using this product.Herbal medicines should not be administered to elderly persons without first consulting a physician.Do not use this product if the box is damaged, deteriorated or the security wrapping is missing.In case of overdose, please contact your nearest poison control center.

Saint Gottard Cascara Sagrada + Aloe.Over the counter.

References
• Las Bases Farmacológicas de la Terapéutica, Séptima Edición1988 - Goodman y Gilman -Pages 948 to 957.
• PDR for Herbal Medicines, Four Edition 2007 -Pages 19 to 26 and 161 to 164.
• Rational Phytotherapy, 1998 - Schulz et al. - Pages 199, 206 to 211.
• Tratado de Fitofármacos y Nutracéuticos, 2007- Dr. Jorge Alonso -Pages 116 to 127 and 271 to 274.

Additional information.The contents of this guide are based on information available in the international scientific literature.Reserved for professional use only.Use for advertising purposes is prohibited.Dietary supplement.Supplements insufficient diets. Consult your physician and/or pharmacist.